S4 Andarine Review: Benefits, Side Effects & Where to Buy?

Updated on July 10, 2020

Selective Androgen Receptor Modulators (SARMs) are defined as a class of therapeutic compounds with similar properties to anabolic steroids, but with decreased androgenic effects. They’re legal, safer, and incredibly effective options for people who want to build muscle mass and maximize their gains.

S4 Andarine is a popular SARM, and you’re probably thinking about giving it a go.

But, can you really draw any benefit from S4 Andarine?

What results to expect?

You probably have tons of questions, but not many answers.

There are many S4 Andarine options out there, but not all of them work equally. Proven Peptides has S4 Andarine in its offer, and although a popular choice by many, you still feel like you don’t know much about it?

This review aims to change that.

In this post, you’re going to learn more about S4 Andarine, how it works, and other useful info every person should know before making a purchase.

What is S4 Andarine? Is it a Steroid & Legal?

S4 Andarine belongs to a group of SARMs (Selective Androgen Receptor Modulators). The SARMs are defined as a class of androgen receptor ligands that bind the androgen receptor and display tissue-selective activation of the androgen signaling. Although they’ve become a popular option for many athletes, bodybuilders, and active people lately, SARMs have been around since the 1940s.

Basically, SARMs produce effects similar to steroids.

While it works to build the muscle mass and help maximize your gains like steroids, it’s not a steroid. S4 Anadrine provides its benefits in a selective way, similar to steroids, but without potentially severe adverse reactions.

S4 Andarine is not actually permissible for professional athletes and competitors. But, they’re easily accessible online and in some stores. One of those options is S4 Andarine from Proven Peptides. That being said, it is specified that these products are intended for laboratory research use only.

Now that we’ve briefly addressed SARMs and the legal status of S4 Andarine let’s focus on this substance.

What’s S4 Andarine, you’re probably wondering.

S4 Andarine, first developed by Kaken Pharmaceuticals Japanese pharmaceutical company, is a SARM specifically developed to prevent muscle wastage and support the development of muscle mass. The use of S4 Andarine is dubbed effective for a chiseled physique characterized by hard, lean, and big muscles. Yet another initial purpose of S4 Andarine was to aid the treatment of osteoporosis and benign prostatic hypertrophy (enlarged prostate).

Also known as Andarin, S-40503, and GTx-007, this SARM doesn’t cause aromatization (conversion of testosterone to estrogen). Unlike other compounds, S4 Andarine doesn’t put too much strain on the liver, nor does it cause suppression of HPTA (hypothalamic pituitary testicular axis).

This SARM can be effectively used for different phases, such as bulking, cutting, and body composition.

Below in this review, you’re going to learn how S4 Andarine works and what benefits you can expect from it.

How does S4 Andarine work?

The whole concept of SARMs, including S4 Andarine may seem complex, but the mechanism of action is simple, actually.

S4 Andarine has a high affinity for the androgen receptor (AR) and works by mimicking the effects of the male hormone testosterone. Since its mechanism of action is selective, the effects of S4 Andarine are more pronounced in bones and muscles than in reproductive organs. That explains why S4 Andarine can help increase muscle mass and provide other benefits but without serious and numerous side effects that would occur with steroid use.

This SARM is fast-acting and produces muscle gains in a relatively short timeframe. Although it’s considered milder than other SARMs, S4 Andarine is still powerful.

It works by binding to the receptors in tissues of your bones and muscles to encourage the growth of lean muscle mass and increase your strength in return. Not only does S4 Andarine have one-third of the binding affinity of testosterone to the AR, but it also has the tremendous potential to make your own testosterone exert a higher effect on muscle mass and protein synthesis than it would usually do.

What are the benefits of S4 Andarine and result expectations?

As seen above, S4 Andarine has a simple and straightforward mechanism of action. This SARM does everything that steroids would do, but in a safer way, which is why it’s a popular choice for many.

Sure, understanding the mechanism of action is one thing, but being aware of the benefits and effects is something else entirely. Below, you can learn more about the benefits of S4 Andarine and results you can expect with regular use.

Bigger muscle mass

Going to the gym regularly and modifying diet plans may still not yield desired results regarding muscle mass. Some people lose confidence and believe that bigger, tighter, and leaner muscles are just not meant to be.

One of the biggest benefits of S4 Andarine is its potential to increase muscle mass. After all, the primary intention behind creating S4 Andarine was to develop SARM to prevent muscle wasting.

The studies involving S4 Andarine were carried out on animals, but their results paint a picture of an effective tool for muscle growth. In one study, castrated mice received S4 Andarine for four weeks and ended up with higher muscle weight, similar to the effects of DHT. Although the effect is the same, there is one huge difference – unlike DHT, S4 Andarine doesn’t increase prostate size. In other words, with S4 Andarine, it’s possible to increase muscle mass without harming the prostate in the process.

A different study showed that treatment with S4 Andarine greatly improved the muscle strength and body composition and restored or prevented lost bone in castrated mice. Scientists concluded that it could be a novel treatment option for problems such as muscle wastage, osteoporosis, and hypogonadism.

In addition to increased size, muscles become harder and more chiseled. It’s also useful to mention that S4 Andarine increases strength and endurance in about two weeks into the cycle. Bigger stamina and intensified endurance can help you break your lift records and thereby amplify your gains.

Increased bone strength

As we age, bone mineral density starts decreasing. Our bones endure a lot on a daily basis, especially while we exercise. The more bone mineral density we lose, the easier they break. Intake of S4 Andarine can increase bone mineral density and make your bones stronger. These effects occur in both female and male users.

What makes S4 Andarine so unique is that in addition to improving bone mineral density, this SARM also has the potential to increase muscle strength. Strong muscles make you more stable and help prevent falls and fractures.

Plus, when you’re working toward increasing muscle mass, you also want to ensure your bones and strong and healthy. S4 Andarine can do both.

Helps lose fat

Probably the most demanding part of achieving a certain body goal is fat loss. Fat, especially in the abdominal area, is stubborn, and it’s not that easy to lose it. The more fat you have, the more difficult it gets to tone muscles, shape them, and increase their size. The greatest concern for many people, especially those who want to try bodybuilding is that regular methods for fat loss would also mean losing a little bit of muscle mass.

S4 Andarine can help you burn fat and therefore shape your muscles at a faster rate. It helps with fat loss because it’s a more androgenic and least anabolic form of SARMs on the market today. When S4 Andarine binds with androgenic receptors in your adipose tissue or fat, a process of fat oxidation begins. That’s why you keep burning fat and get better results in the gym.

Additionally, S4 Andarine suppresses the production of hormone-sensitive lipase, which helps to regulate the metabolism of stored fat. It does so by signaling the body to use that fat for energy. This could be particularly beneficial for people with a slow metabolism. When metabolism is slow, the body is unable to burn fat and calories as quickly as it should to achieve weight loss or help you build muscles.


The telltale sign of remarkable progress in the gym is the noticeable web of veins clearly visible on the body. Most people want to achieve that look, but it takes hard work to get it. S4 Andarine can be a practical addition to your effort. As it keeps pumping your muscles and blood, S4 Andarine can also increase vascularity. In most cases, the results show up in the first two or three weeks of the S4 Andarine cycle and may last for up to six weeks post-cycle.

What results to expect

Benefits of S4 Andarine are truly impressive, but it’s important to clarify one thing. Results depend on the quality of the product you buy. The goal should be to buy high-quality S4 Andarine, not an item that doesn’t live up to the standards and expectations.

To sum up benefits, with regular and proper use of S4 Andarine, you can experience the following results:

  • Increased muscle strength
  • No water retention
  • Results visible fast
  • Improved athletic performance e.g., intensity and endurance at which you lift more weight or hit the track
  • Increased vascularity
  • Muscles look rock hard.
  • Burns fat quickly
  • Helps oxidize fat and prevents the body from getting catabolic when you’re on a low-calorie diet
  • Fit, lean, chiseled body
  • Confidence boost
  • Increased self-esteem
  • More energy

Maximum safe dosage

Ideally, you should divide S4 Andarine into three separate doses that equal to 25-30mg a day. This dosage isn’t high, but it’s in an optimal safe range. While some people take 50 to 70mg a day, you shouldn’t do so at the very beginning.

You may stumble upon stories where people use 100mg of S4 Andarine a day. This dosage is high, and the safest thing to do is to avoid it in order to reduce the risk of side effects.

Basically, if you’ve never used S4 Andarine before, you should start with the lowest dose and work your way up if necessary.

Side effects of S4 Andarine

At low doses, S4 Andarine is unlikely to cause serious side effects. At higher doses, some people may experience temporary changes in vision. What happens is that some people may see incorrect colors or yellowish tinge when looking at things.

This happens due to a metabolite of S4 binding to vision receptors. When the body gets used to S4 Andarine, this problem goes away on its own.

It’s also useful to mention that some users may experience slight testosterone suppression when taking S4 Andarine. By the time the S4 Andarine cycle is over, you may feel increased fatigue and weakness. Some people may experience nausea and frequent headaches. But keep in mind that not all users of S4 Andarine feel this way.

The testosterone suppression due to S4 Andarine can be corrected with PCT and by keeping your cycle at the recommended length.

The risk of adverse reactions increases with high doses. For that reason, it’s crucial to stick to the dosage instructions provided by the manufacturer.

Many people are seduced by low potency of S4 Andarine compared to other SARMs and feel free to take higher doses. But this is not always recommended.

To help your body recover, it’s practical to start with post-cycle therapy once your S4 Andarine cycle is over.

Where can you buy S4 Andarine?

The best way to get genuine S4 Andarine is to purchase it straight on the Proven Peptides website. The prices are as follows:

  • 15ml – $44.99
  • 30ml – $74.99
  • 60ml – $139.99

Purchasing S4 Andarine from the official website of the brand is the best way to ensure you don’t get a low-quality product or item that isn’t genuine. Other benefits of buying on the website are included below.

Third-party testing

Proven Peptides sends its products, including S4 Andarine, to independent laboratories for third-party testing. The third-party practice testing helps confirm the purity and quality of a product. This way, brands confirm their claims about the product are accurate. All third-party testing results are available on the official website, here. Each batch of S4 Andarine is tested, which also gives you a dose of confidence regarding the safety of the product.

Loyalty points

Proven Peptides has a loyalty program for their customers. The program is simple; for each dollar spent on the website, you get one point. For example, for $44.99, you get 45 points.

The number of points you can get with the purchase is displayed under the price of a product.

Each point can be redeemed for 10 cents off the next order. In other words, you get 10% off.

Participation in the loyalty program is easy; you just need to create an account at Proven Peptides, and that’s it. Just by signing up on the website, you’ll get 10 points automatically.

Available internationally

While some brands offer their products in a specific country e.g., the United States, Proven Peptides ships S4 Anadrine and other items internationally.

Money-back guarantee

The US customers who aren’t satisfied with their product can return it within 90 days for a full refund. Just keep in mind that the costs of shipping aren’t covered.

When it comes to international customers, if S4 Andarine doesn’t make it through US customs, Proven Peptides offers a full refund. But if the product goes through the US customs successfully and is held by foreign customs, then you won’t get your money back. If your product arrives and you’re not satisfied with it for some reason, you can return it and get your money back too.

The return procedure is easy. Customers just need to contact the support center by sending an email to [email protected].

The money-back-guarantee and the process of returning the product is a lot more convenient than in other physical or online stores. The money-back-guarantee period is usually 30 to 60 days in most cases.

Fast handling and shipping

Proven Points has a maximum of one business day handling period for all orders placed via credit or debit card. In other words, if a credit card is the payment method of choice, then the order is shipped within one business day.

The handling period for eCheck payments is up to three days. Payments made by bank transfer may take a few hours or possibly a day or more to clear. The brand ships the product immediately after the payment is cleared, so you won’t have to wait long to get your S4 Andarine.

Packages are sent via USPS First Class (or USPS Priority if the order weighs enough) and arrives at the address of the US customers within three days.

FAQs about S4 Andarine

How long can you take S4 Andarine?

Every brand explains the consumption method on the label, and it’s important to stick to them. Generally speaking, you may need to take S4 Andarine for five days a week, followed by a two-week-long break. This cycle usually lasts 10 to 12 weeks, but you should go for eight weeks as an optimal safe cycle length.

How long does S4 Andarine stay in your system?

The half-life of S4 Andarine is four to six hours. The best thing about S4 Andarine is that it doesn’t aromatize, thus preventing the excess release of estrogen, which would induce various side effects otherwise.

Do you need PCT after S4 Andarine?

You may have to use post-cycle therapy (PCT) after the most SARM cycles, including S4 Andarine. The main objective of PCT is to restore normal levels of testosterone while combating potential side effects. The human body is clever, and when testosterone levels increase, so does the estrogen.

With PCT, it can be easier to maintain all the gains you’ve achieved with the S4 Andarine cycle. Some SARMs don’t need PCT, especially at low doses. In this case, you don’t need potent PCT; milder options will suffice. The recovery time after S4 Andarine is short, two to three weeks upon completion of the cycle.

Can women take S4 Andarine?

Yes, they can. Although men are the ones who usually take S4 Andarine to pump their muscles, this SARM is safe for women as well. Of course, if you’re pregnant or breastfeeding, you shouldn’t use this or any other SARM and dietary supplement before consulting your doctor.

Can you drink alcohol on SARMs, including S4 Andarine?

No. At least you shouldn’t! You see, SARMs are processed by the liver, so the consumption of alcohol could add more stress to the liver and impair its function.

Is S4 Andarine good for cutting?

Yes, it is. In fact, the benefits of S4 Andarine for cutting are underrated. This SARM shines in the cutting cycle during which it amplifies the rate of lipolysis, increases muscle pumps, and promotes vascularity.

Can you stack S4 Andarine with other SARMs?

Yes, you can. One of the greatest benefits of S4 Andarine is its versatility. It can work with other SARMs, especially Ostarine and GW501516 or Cardarine. You can also stack S4 Andarine with Ligandrol.

Conclusion: Should You Buy S4 Andarine?

The main objective of this post was to provide useful information about the safety and efficacy of S4 Andarine. As seen above, S4 Andarine has some pretty amazing benefits which could explain its popularity among bodybuilders and active people. Although S4 Andarine can exhibit positive results, which many users confirm, it’s still necessary to carry out further studies on this subject. Studies evaluating S4 Andarine used animals, and despite the fact the results apply to humans, it’s still needed to investigate the safety and efficacy of S4 Andarine in a more detailed manner.

If you plan to use S4 Andarine, you should stick to a safe dosage ratio and follow it up by short PCT. The legal status of S4 Andarine is also a major subject as pro athletes can’t (or shouldn’t) use it, and the manufacturers specify the SARM is for research use only. However, you may want to connect with other people who have used or plan to use S4 Andarine to compare your experiences.

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