University Hospitals Makes History as First Major Health System to Partner with OneDose

OneDose® electronic Medication Administration Cross-Check™ (eMACC) is a first-of-its-kind medication safety innovation built specifically for EMS. This new technology modernizes the proven Medication Administration Cross-Check® (MACC) into a digital, single-provider workflow that reduces medication errors without slowing patient care.

Developed in partnership between OneDose and Dr. Paul Misasi (creator of MACC®), the
electronic system eliminates human bias during medication verification, reduces wrong-vial and
wrong-dose errors, and creates a clear, time-stamped, digital verification trail.

eMACC brings medication safety standards that have been shown to reduce errors by more than 40% directly into the hands of EMS clinicians and out-of-hospital providers. —John Hill, MD, EMS Medical Director, University Hospitals of Cleveland

Early in eMACC development, the EMS Institute at University Hospitals Cleveland (UH)
became involved in the application’s beta testing. UH’s involvement is a milestone, not only for
the hospital, but also for OneDose, as it is their first collaboration with a large-scale hospital
system.

University Hospitals was introduced to OneDose after receiving a cold marketing call, selling
another OneDose product. Dr. John Hill, EMS Medical Director at UH, inquired about the
system and suggested that it should be purchased for the UH region.

“In January 2025, we rolled out the OneDose app as our centralized location for our protocol,”
said Dr. Hill. “This past fall, we became part of their eMACC testing because we’ve grown this
relationship as one of their trusted partners.”

VIDEO SAMPLE: Dr. Hill and paramedics demonstrate the new eMACC app in
practice emergency medical scenarios (https://youtu.be/uCI5YFtUbao), learning
how to use OneDose to verify medication, concentration, and dose calculations prior
to administration.

“University Hospitals continues to lead the way in prehospital innovation,” said Tristen Hazlett,
Founder and Chief Executive Officer of OneDose. “Collaborating directly with UH leadership
has helped shape OneDose into a platform capable of supporting large-scale systems. The
system-wide deployment of eMACC sets a new benchmark for medication safety across more
than 300 EMS agencies.”

At the beginning of each year, UH releases updated protocols and medication changes in a large
430-page PDF document. Now, instead of reworking a master protocol document, the changes
are implemented and sent out to EMS providers through the OneDose app.

“Anytime I’m talking about dosing medication or giving training, and providers are asking me
for advice, my response is always, ‘Well, let’s see what protocol says,’” said Dr. Hill. “We pull
up OneDose, which has become our single source for all information. OneDose allows us to
better communicate with our EMS providers and make faster updates to protocol than I could
before with email and changing a big PDF.”

“At University Hospitals EMS Institute, our responsibility is to ensure that the clinicians serving
our communities have the safest, most reliable tools available. The first system-wide deployment
of OneDose across Ohio represents a major advancement in out-of-hospital patient safety,” said
Dr. Donald Spaner, Chief Medical Officer and EMS Medical Director at UH. “Through enhanced
medication verification with eMACC, rapid access to up-to-date protocols, and integrated
resuscitation support tools, OneDose strengthens clinical decision-making in the moments that
matter most.”