How to Dispose of Medical Waste

Updated on May 21, 2025

Medical waste, also referred to as biohazardous or regulated medical waste, is generated by hospitals, clinics, laboratories, and even home healthcare providers. It includes materials contaminated with bodily fluids, sharps (needles, scalpels), pharmaceutical waste, and more. Improper disposal can lead to infections, environmental pollution, and legal penalties.

In this guide by TriHaz Solutions, we walk through the critical steps and technologies involved in the safe and compliant disposal of medical waste.

1. Understanding the Categories of Medical Waste

Medical waste is not one-size-fits-all. It must be carefully categorized before disposal. Common categories include:

  • Sharps: Needles, scalpels, syringes.
  • Pathological Waste: Human tissues, organs.
  • Pharmaceutical Waste: Expired or unused medications.
  • Chemical Waste: Lab reagents or cleaning agents.
  • Microbiological Waste: Cultures, Petri dishes.
  • Contaminated Soft Waste: Bandages, gowns, gloves.

2. Segregation at the Source

Proper medical waste disposal begins with segregation at the point of generation. This means separating different types of waste immediately as they are produced, using clearly labeled, color-coded, and purpose-specific containers. 

For example, red bags are designated for infectious waste, while yellow containers are used specifically for trace chemotherapy waste. 

Black containers are reserved for RCRA-regulated hazardous pharmaceutical waste. Sharps, such as needles and scalpels, must be disposed of in puncture-resistant containers designed to prevent injury and leaks.

3. Safe Storage and Handling

Medical waste must be stored in containers that are secure, leak-proof, and puncture-resistant, with tight-fitting lids to prevent accidental exposure or spills. These containers should be clearly marked with biohazard symbols to signal the presence of potentially infectious materials. 

To maintain safety and compliance, all medical waste should be kept in areas that are locked or have restricted access, limiting exposure only to authorized personnel. Additionally, anyone handling these containers must be properly trained and equipped with appropriate personal protective equipment (PPE) to ensure their safety and to prevent the spread of contamination.

4. Treatment and Disposal Methods

Proper treatment of medical waste is essential to neutralize potential hazards and comply with federal and state regulations. Several methods are employed, each suitable for specific waste types and operational needs. Below are the most common and effective methods used in healthcare facilities.

Incineration

Incineration involves burning medical waste at high temperatures in a controlled environment. It is particularly effective for disposing of pathological waste, pharmaceutical waste, and chemically contaminated materials. This method destroys up to 99.99% of pathogens and can reduce the volume of waste by as much as 90%, making it a highly efficient solution for hazardous waste.

However, incineration is not permitted in all states due to environmental concerns. It also requires strict compliance with EPA air pollution control standards, making it a more heavily regulated and infrastructure-intensive option.

Autoclaving (Steam Sterilization)

Autoclaving uses high-pressure steam to sterilize medical waste, making it safe for final disposal. It is best suited for items like sharps, microbiological waste, and soft, non-chemical contaminated waste such as bandages and gowns. This method is widely used because it is environmentally friendly and highly effective at killing microbial life.

Chemical Disinfection

Chemical disinfection involves treating waste with disinfectants such as chlorine, formaldehyde, or iodine. It is particularly useful for liquid biological waste, like blood and bodily fluids, as well as certain types of laboratory waste. This method can be implemented on-site and is often considered cost-effective for facilities with the appropriate equipment and training.

Microwave Treatment

Microwave treatment uses controlled microwave energy to disinfect medical waste. It is primarily used for moist, non-sharp contaminated waste, such as gauze, bandages, and other absorbent materials. This method is energy-efficient, generates low emissions, and does not require combustion, making it an attractive option for environmentally conscious facilities.

5. Transportation & Cradle-to-Grave Responsibility

In the healthcare industry, managing medical waste doesn’t end once it leaves the facility. Under the cradle-to-grave responsibility outlined by the Environmental Protection Agency (EPA), hospitals and all other medical waste generators are legally responsible for the waste they produce from the moment it is generated until it reaches its final point of disposal. This obligation holds true even when third-party haulers or treatment facilities are used.

Transport Requirements

Transportation of medical waste must adhere to strict regulatory standards to prevent environmental contamination and ensure public safety. Only licensed and trained medical waste haulers are permitted to handle the transport process. Every shipment must be accompanied by proper documentation, typically a manifest, in accordance with 40 CFR regulations. These manifests help track waste through each stage of its journey, often using GPS or manifest-tracked routes to verify its secure and compliant handling.

Generator Classifications

The EPA categorizes waste generators based on the quantity of hazardous waste they produce. These classifications include:

  • Very Small Quantity Generators (VSQGs) – Facilities generating less than 100 kg of hazardous waste per month.
  • Small Quantity Generators (SQGs) – Facilities producing between 100 kg and 1,000 kg per month.
  • Large Quantity Generators (LQGs) – Those generating more than 1,000 kg monthly.

Each classification comes with specific regulations concerning storage limits, treatment timeframes, and record-keeping requirements. For example, LQGs must generally treat or dispose of hazardous waste within 90 days and adhere to additional containment and reporting rules.

By understanding and complying with these classifications, medical facilities can better ensure regulatory compliance and minimize liability throughout the waste management process.

6. State Compliance & Environmental Laws

Medical waste disposal in the United States is governed by both federal and state regulations, with the foundational framework provided by the Resource Conservation and Recovery Act (RCRA). While all states are required to follow RCRA regulations, many state laws are more stringent and impose additional requirements to address local environmental concerns.

Federal Standards and Oversight

Under federal law, medical waste incinerators must comply with Section 129 of the Clean Air Act, which mandates strict emission controls to limit air pollutants and ensure public safety. These rules are enforced by the Environmental Protection Agency (EPA) and require continuous monitoring and adherence to the best available technology for emissions reduction.

Another key regulation is EPA Subpart P, which specifically outlines how hazardous waste pharmaceuticals must be managed. This includes proper containerization, labeling, and disposal practices designed to minimize risks to both human health and the environment.

Storage Limitations for Generators

Large Quantity Generators (LQGs) face additional constraints, particularly when it comes to storage. Generally, LQGs may only store hazardous waste on-site for up to 90 days, although limited exceptions may apply under certain conditions. This rule ensures that waste does not accumulate in volumes that could pose safety risks or regulatory violations.

Why State Laws Matter

In addition to federal oversight, state environmental agencies often introduce regulations that are more restrictive than federal baseline standards. For instance, some states ban or limit medical waste incineration altogether due to air quality concerns, while others impose tighter timeframes for storage or more

7. Common Questions

Q: How is Liquid Medical Waste Handled?

Liquid medical waste, such as blood and bodily fluids, must be collected in leak-proof, clearly labeled containers specifically marked for biohazardous content. Once segregated from other waste streams, treatment methods may include chemical disinfection, autoclaving (if the waste type is compatible), or removal by a licensed third-party medical waste disposal service. Facilities must follow both federal and state guidelines to ensure the safe handling and treatment of all liquid waste.

Q: What Goes in the Black Bin?

Black bins are typically used for RCRA hazardous pharmaceutical waste, including:

  • Expired or unused hazardous medications
  • P-listed and U-listed pharmaceuticals
  • Contaminated packaging from hazardous drugs

Q: What Goes in the Yellow Bin?

Yellow bins are designated for trace chemotherapy waste and related hazardous materials. This includes:

  • Empty IV bags, tubing, and syringes with chemotherapy drug residue
  • PPE (gloves, gowns, masks) used in handling chemotherapy
  • Empty vials or containers that held chemotherapy agents

Q: How Do You Dispose of Biohazard Waste?

Biohazard waste, including items contaminated with blood, body fluids, or infectious agents, should be placed in red biohazard bags or appropriately labeled sharps containers. These items are then treated via autoclaving, incineration, or chemical disinfection, depending on the facility’s resources and waste type. After treatment, waste may be landfilled as non-infectious material. It’s critical to follow local and federal regulations to avoid health risks and penalties.

Q: How Do You Tie a Red Bag?

Tying a red biohazard bag properly is essential to prevent leaks and exposure. Follow these steps:

  1. Twist the top of the bag tightly to remove excess air.
  2. Tie it using a gooseneck knot—a tight twist and fold secured with a knot or zip tie.
  3. Ensure the knot is secure and tight to maintain containment.
    Never overfill the bag, and always place it in a rigid, labeled biohazard container for transport.

Q: What Goes in a Biohazard Bag?

Biohazard bags are used for soft, non-sharp waste contaminated with infectious materials, including:

  • Used bandages, gauze, and dressings
  • PPE contaminated with blood or bodily fluids
  • Disposable surgical instruments (non-sharp)
  • Cultures and lab specimens
    Items that drip, flake, or ooze infectious matter must go into a red biohazard bag. Sharps must be disposed of in a puncture-resistant sharps container—not in a red bag.

Cost-Effective Hospital Waste Management Solutions

Reducing waste volume through on-site treatment, staff training, and proper segregation can significantly reduce costs.

Some hospitals invest in autoclaves or container management systems. Others partner with providers like TriHaz Solutions, offering:

  • Sharps, chemo, pharmaceutical, and pathological waste solutions.
  • Waste audits and compliance consulting.
  • Custom waste stream optimization programs.
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The Editorial Team at Healthcare Business Today is made up of experienced healthcare writers and editors, led by managing editor Daniel Casciato, who has over 25 years of experience in healthcare journalism. Since 1998, our team has delivered trusted, high-quality health and wellness content across numerous platforms.

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