Best Weight Loss Supplements in 2024: Natural Fat Burners That Work

Updated on December 12, 2023

Losing weight isn’t easy, even with the best diet and exercise routine. Fortunately, certain weight loss supplements can help you lose weight faster by improving your energy levels, boosting your metabolism, and suppressing your appetite.

PhenQ is # 1 in our list of the best weight loss supplements because it reduces cravings, promotes fat-burning, increases energy, and improves overall health. Still, other diet products may suit you better based on your fitness goals.

This article will cover 13 of the best weight loss supplements, so you can compare their pros, cons, and ingredients.

Best Weight Loss Supplements

1. PhenQ – Best Weight Loss Supplements Overall – 4.9/5

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  • Caffeine promotes thermogenesis and reduces appetite
  • Nopal powder may decrease body fat and lower blood pressure
  • Two-month refund 
  • Free delivery


  • Relatively expensive

Who Is PhenQ Best For?

PhenQ might be the right choice if you are looking for the best weight loss supplements that offer multiple benefits.

One of the ingredients in PhenQ, a-Lacys Reset, can help you lose weight without losing muscle mass [1]. Nopal powder can prevent the body from accumulating fat [2].

Who Should Avoid PhenQ?

PhenQ is not advisable for people taking prescriptions. The lipoic acid in a-Lacys Reset may interact with some diabetic medications, whereas carnitine may interfere with certain antibiotics [3]. 


PhenQ is one of the best weight loss supplements that contain various ingredients that work together to reduce weight. The blend of nopal powder and caffeine could enhance energy and metabolism while reducing body fat.

>>Check the best prices for PhenQ

2. Keto Charge – Best for Keto Dieters – 4.8/5

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  • Encourages ketosis
  • Prevents keto flu
  • Suppresses appetite
  • Supports bone health


  • No individual ingredient dosages

Who Is Keto Charge Best For?

Keto Charge is one of the best keto supplements for people following the ketogenic diet to lose weight and slim down.

It contains BHB salts that promote a state of ketosis and minimizes the symptoms of the keto flu.

Who Should Avoid Keto Charge?

Individuals who are not on a keto diet can find more comprehensive alternatives.


Keto Charge can serve as the best weight loss supplements that can help keto dieters stay on track and stick to their eating plan.

>>Check the best prices for Keto Charge

3. Phen24 – Best for Round-the-Clock Support – 4.7/5


  • Provides daytime energy
  • Prevents nighttime cravings
  • Encourages fat-burning


  • Expensive pricing
  • May interact with antidepressants

Who Is Phen24 Best For?

Phen24 is one of the best weight loss supplements for men and women who prefer a two-in-one solution.

The day formula contains guarana extract and caffeine that can increase energy levels. The night formula includes griffonia, which may boost serotonin levels through its 5-HTP content.

Who Should Avoid Phen24?

Phen24 is not recommended for those taking antidepressant medications.


Phen24 is unique among the best weight loss supplements because it comprises two formulas for all-day, all-night support.

>>Check the best prices for Phen24

4. PrimeShred – Best for Boosting Metabolism – 4.6/5

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  • Enhances metabolism
  • Suppresses hunger
  • 100-day refund policy.


  • Refund limitations

Who Is PrimeShred Best For?

PrimeShred utilizes caffeine, green tea extract, and cayenne powder to speed up your metabolic rate, while a blend of tyrosine and theanine promotes relaxation and focus.

Who Should Avoid PrimeShred?

Tyrosine in PrimeShred might affect the effectiveness of certain antidepressants like MAOI. 


PrimeShred is considered one of the best weight loss supplements that can assist you to get your desired body shape rapidly by improving your metabolism.

>>Check the best prices for PrimeShred

5. CalmLean – Best Stim-Free Formula – 4.5/5

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  • Doesn’t contain stimulants
  • Encourages thermogenesis
  • Reduces fat accumulation


  • Not as potent as other supplements

Who Is CalmLean Best For?

CalmLean is one of the best weight loss supplements for those who are sensitive to caffeine. Its formula is free from stimulants like caffeine, so it’s not likely to cause you jitters.

Its capsaicin content raises your body temperature to support fat-burning. ForsLean, an extract from Coleus forskohlii, may reduce insulin to prevent fat storage.

Who Should Avoid CalmLean?

Active individuals who need a more stimulating supplement may look for more potent options.


CalmLean is a gentle alternative to the other best weight loss supplements because of its stimulant-free formulation.

>>Check the best prices for CalmLean

6. Brutal Force ACUT – Best Anavar Alternative – 4.⅘

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  • Legal substitute for Anavar
  • Encourages fat loss
  • Maintains muscle mass


  • Whey and soy are potential allergens

Who Is Brutal Force ACUT Best For?

Brutal Force ACUT is one of the best weight loss supplements for those looking for a natural alternative to Anavar. It has comparable effects as the steroid but has fewer health risks.

The main ingredients are soy and whey protein isolate, which can help eliminate body fat. It also includes BCAAs that prevent muscle loss even when you eat less.

Who Should Avoid Brutal Force ACUT?

People allergic to soy or whey should steer clear of ACUT.


Brutal Force ACUT is known among the best weight loss supplements as a legal alternative to Anavar that can be used during cutting cycles.

>>Check the best prices for Brutal Force ACUT

7. Brutal Force WINCUT – Best Winstrol Substitute – 4.4/5

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  • Natural alternative to Winstrol
  • Supports fat-burning
  • Improves mental focus


  • Limited ingredient list

Who Is Brutal Force WINCUT Best For?

Brutal Force WINCUT could work as the best weight loss supplements for those who need a legal substitute for Winstrol. It aims to provide similar benefits as the steroid while having a lower risk of side effects.

WINCUT comes with choline that helps burn fat for energy. It also includes DMAE that sharpens your focus during workouts.

Who Should Avoid Brutal Force WINCUT?

Individuals who prefer a supplement with more ingredients may consider other alternatives.


Brutal Force WINCUT is marketed as a natural Winstrol alternative among the weight loss supplements that are counted as legal steroids.

>>Check the best prices for Brutal Force WINCUT

8. Trimtone – Best for Belly Fat – 4.3/5

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  • Caffeine increases energy levels and speeds up metabolism
  • Glucomannan decreases hunger and reduces food cravings 
  • 100-day refund


  • Certain ingredients are present in minimal quantities

Who Is Trimtone Best For?

Trimtone is one of the best weight loss supplements that can help adult women and men shed extra belly fat and achieve their desired weight.

Glucomannan reduces appetite, while caffeine boosts metabolism.

Who Should Avoid Trimtone?

Trimtone is not recommended for pregnant or nursing women and caffeine-sensitive individuals.


Trimtone is counted among the best weight loss supplements that can reduce belly fat by curbing appetite and improving metabolism.

>>Check the best prices for Trimtone

9. Instant Knockout Cut – Best for Men – 4.3/5



  • Contains essential vitamins
  • Caffeine may boost energy and increase metabolism
  • Glucomannan could minimize hunger


  • Comparatively costly
  • High caffeine content

Who Is Instant Knockout Best For?

Instant Knockout is one of the best weight loss supplements specifically designed for men aiming to lower their body weight

Additionally, it provides essential vitamins such as D, B5, and B12, which are often insufficient in male diets.

Who Should Avoid Instant Knockout?

Instant Knockout is not advisable for caffeine-sensitive individuals due to its caffeine-rich formula.


Instant Knockout is counted among the best weight loss supplements that enhances metabolism and physical endurance while reducing appetite.

>>Check the best prices for Instant Knockout Cut 

10. Zotrim – Best for Appetite Control – 4.2/5

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  • Reduces hunger pangs
  • Increases energy
  • Promotes fat-burning


  • Caffeine-rich formula

Who Is Zotrim Best For?

Zotrim is one of the best weight loss supplements for people who want to lower their calorie intake by curbing cravings.

It features yerba mate, damiana, and guarana that may aid in appetite suppression, while the caffeine in guarana encourages your body to burn fat. Moreover, B vitamins can provide extra energy.

Who Should Avoid Zotrim?

Persons sensitive to caffeine might find Zotrim too stimulating.


Zotrim is counted among the best weight loss supplements that can assist people in controlling their appetite, so they can eat less.

>>Check the best prices for Zotrim

11. Powher – Best for Energy – 4.2/5

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  • Supports fat-to-energy conversion
  • Curbs appetite
  • Minimizes fat absorption


  • Glucomannan may affect medicine absorption

Who Is Powher Best For?

Powher could serve as the best weight loss supplements for individuals who need a boost of energy.

The formula contains choline, which can help the body burn fat as energy. Furthermore, glucomannan can lessen hunger pangs while limiting the amount of fat absorbed by your digestive system.

Who Should Avoid Powher?

Powher is not advisable if you are taking prescription medications, since glucomannan may reduce the absorption of medicine.


Powher is counted among the best weight loss supplements that can provide extra energy during exercise.

>>Check the best prices for Powher

12. Leanbean – Best for Women – 4.1/5

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  • Contains essential B vitamins 
  • Carnitine may improve metabolic rate
  • Glucomannan can curb hunger


  • Six pills daily

Who Is Leanbean Best For?

Leanbean is one of the best weight loss supplements formulated for women. Its thermogenic nutrients and essential nutrients can increase metabolism to reduce weight and eliminate belly fat.

It includes glucomannan, which can decrease the desire for food [7]

Who Should Avoid Leanbean?

Leanbean contains only minimal caffeine, so look for a more potent alternative if you need a supplement that provides more energy.


Leanbean stands among the best weight supplements because it is designed to help women reach their fitness goals by suppressing their appetite and boosting metabolism.

>>Check the best prices for Leanbean

13. Transparent Labs – Best for Menopause – 4.1/5

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  • White willow could reduce inflammation
  • Caffeine and synephrine may boost energy levels and metabolic rate
  • 5-HTP, tyrosine, and theanine can enhance emotional well-being and state.


  • No free delivery

Who Is Transparent Labs Best For?

Transparent Labs’ Fat Burner is one of the best weight loss supplements for menopausal women wishing to lose weight. The supplement includes caffeine and synephrine, which can enhance energy and metabolism to break down fat cells [4]. 

Additionally, the serotonin-boosting amino acid 5-HTP may enhance mood [5]. Other ingredients include theanine and cayenne pepper extract.

Who Should Avoid Transparent Labs?

If you have a cardiac condition, avoid using products with synephrine as it may worsen your condition.


Transparent Labs is counted among best weight loss supplements for women undergoing menopause since it can help with weight loss’s psychological and emotional aspects.

>>Check the best prices for Transparent Labs

Best Weight Loss Supplements: FAQs

Here, we answer a few frequently asked questions about the best dietary supplements for weight loss.

What Are the Best Weight Loss Supplements That Work?

The best weight loss supplements are those that provide a great combination of natural ingredients, a reasonable price, and a reliable customer satisfaction guarantee. 

What Are the Number One Best Weight Loss Supplements Today?

PhenQ is #1 in our list of the best weight loss supplements because of its potent ingredients, fat-burning benefits, easy accessibility, money-back guarantee, and free shipping.

Are There Supplements That Make You Lose Weight Fast?

Yes, the best weight loss supplements can help you shed pounds when used with a healthy diet and regular exercise. The best fat burners can assist in lowering your body weight by reducing body fat, curbing appetite, improving metabolism, and enhancing energy.

Best Over the Counter Weight Loss Supplements: Final Thoughts

Overall, we discovered that PhenQ stands out among the best weight loss supplements on the market. It contains scientifically backed ingredients that stimulate thermogenesis, increase energy, and suppress appetite to help you reach your weight loss goals

Remember that supplements can have varying effects on different individuals. Make sure to do your research and select the best weight loss supplements that best meet your specific needs and health status.

>>Check the best prices for PhenQ


  1. Kucukgoncu, S., et al. “Alpha-Lipoic Acid (ALA) as a Supplementation for Weight Loss: Results from a Meta-Analysis of Randomized Controlled Trials: Alpha-Lipoic Acid (ALA) for Weight Loss.” Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, vol. 18, no. 5, 2017, pp. 594–601, doi:10.1111/obr.12528.
  2. Onakpoya, Igho J., et al. “The Effect of Cactus Pear (Opuntia Ficus-Indica) on Body Weight and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.” Nutrition, Elsevier, 19 Dec. 2014,
  3. “L-Carnitine.” Linus Pauling Institute, 3 Jan. 2022,
  4. Gutiérrez-Hellín, Jorge, and Juan del Coso. “Effects of P-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise.” Medicine and Science in Sports and Exercise, vol. 50, no. 9, 2018, pp. 1899–1906, doi:10.1249/mss.0000000000001653.
  5. Maffei M. E. (2020). “5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology.” International journal of molecular sciences, 22(1), 181.
  6. Leung, Felix W. “Capsaicin as an Anti-Obesity Drug.” SpringerLink, Springer Basel, 1 Jan. 1970,

Guo, Liping, et al. “Konjac Glucomannan Molecular and Rheological Properties That Delay Gastric Emptying and Improve the Regulation of Appetite.” Food Hydrocolloids, Elsevier, 11 May 2021,

The Editorial Team at Healthcare Business Today is made up of skilled healthcare writers and experts, led by our managing editor, Daniel Casciato, who has over 25 years of experience in healthcare writing. Since 1998, we have produced compelling and informative content for numerous publications, establishing ourselves as a trusted resource for health and wellness information. We offer readers access to fresh health, medicine, science, and technology developments and the latest in patient news, emphasizing how these developments affect our lives.