Best Weight Loss Supplements 2025: Top Dietary Products for Quick Fat Loss

Losing weight isn’t easy, even with the best diet and exercise routine. Fortunately, certain weight loss supplements can help you lose weight faster by improving your energy levels, boosting your metabolism, and suppressing your appetite.

PhenQ is # 1 in our list of the best weight loss supplements because it reduces cravings, promotes fat-burning, increases energy, and improves overall health. Still, other diet products may suit you better based on your fitness goals.

This article will cover 9 of the best weight loss supplements so you can compare their pros, cons, and ingredients.

Best Weight Loss Supplements: Quick Overview

1. PhenQ – Best weight loss supplement overall
2. Phen24 – Best for round-the-clock support
3. Keto Charge – Best for keto dieters
4. PrimeShred – Best for boosting metabolism
5. CalmLean – Best stim-free formula
6. Trimtone – Best for women
7. Instant Knockout Cut – Best for men
8. Zotrim – Best for appetite control
9. Transparent Labs Body Recomp – Best diet pills for body recomposition

1. PhenQ – Best Weight Loss Supplement Overall

Pros

• Recommended by 507 physicians on FrontrowMD
• 60-day money-back guarantee
• Suitable for vegetarians and vegans
• Subscribers get 15% off
• Free meal shake with bulk orders

Cons

• Free shipping only on bulk orders

Who Is PhenQ Best For?

PhenQ might be the right choice if you are looking for the best weight loss supplements that offer multiple benefits. It’s well-suited for individuals who struggle with various aspects of weight management, such as cravings, low energy, and fat accumulation.

Who Should Avoid PhenQ?

PhenQ is not advisable for people taking prescriptions. The lipoic acid in a-Lacys Reset may interact with some diabetic medications, whereas carnitine may interfere with certain antibiotics.

Price

• 1 month supply costs $69.99
• 3 months supply costs $139.99
• 5 months supply costs $209.99

Dosage

• 1 pill with breakfast and another one with lunch

User Review

PhenQ has received mixed feedback online. One customer on the PhenQ official website shared an impressive 44-lb weight loss in 3 months by combining it with a healthy diet and exercise [1]. However, a Trustpilot reviewer felt the energy boost was minimal and found the product overpriced [2].

>>Buy PhenQ here

2. Phen24 – Best for Round-the-Clock Support

Pros

• Dual weight loss formula
• First-time buyers get a special discount code
• 100% vegetarian and vegan friendly
• 60-day money-back guarantee

Cons

• May interact with antidepressants

Who Is Phen24 Best For?

Do you struggle to get some exercise in the morning or even get out of bed? Or are you having an ongoing battle with evening or midnight cravings? Phen24 may be a solution to consider if you can relate to these issues. 

The day formula contains guarana extract and caffeine, which can increase energy levels and help you start your day on a high note. The night formula is stimulant-free and includes Griffonia, which may help you reduce those pesky cravings.

Who Should Avoid Phen24?

Phen24 is not recommended for those taking antidepressant medications.

Price

• 1 month supply costs $69.99
• 3 months supply costs $139.99
• 5 months supply costs $209.99

Dosage

• 1 pill in the morning with breakfast
• 2 capsules of the night formula with water 15 minutes before your evening meal

User Review

John Lane gave the supplement a 4-star rating on Trustpilot, noting increased energy for his workouts and reduced late-night cravings [3]. However, some customers, like Michael Sitton, reported shipping issues, citing delayed deliveries and unhelpful customer service [4].

>>Get Phen24 here

3. Keto Charge – Best for Keto Dieters

Pros

• 60-day money-back guarantee
• Straightforward dosage
• Clean and simple formulation
• Bigger savings with bulk orders

Cons

• No individual ingredient dosages

Who Is Keto Charge Best For?

Keto Charge is formulated to help people following the ketogenic diet lose weight and slim down. It contains a proprietary blend of BHB salts that may promote a state of ketosis and minimize the symptoms of the keto flu.

Who Should Avoid Keto Charge?

Individuals who are not on a keto diet can find more comprehensive alternatives.

Price

• 1 month supply costs $59.99
• 3 months supply costs $119.99
• 5 months supply costs $179.99

Dosage

• 2 capsules with a glass of water daily

User Review

The official KetoCharge website lacks balanced reviews. For a more comprehensive perspective, consider exploring third-party platforms.

>>Explore Keto Charge weight loss benefits

4. PrimeShred – Best for Boosting Metabolism

Pros

• Free of soy, gluten, and dairy
• Vegan and vegetarian-friendly
• 100-day refund policy
• 20% off when you subscribe

Cons

• Refund limitations

Who Is PrimeShred Best For?

A higher metabolic rate generally means your body burns more calories at rest. If this sounds like something you lack, you should try PrimeShred. The supplement includes natural ingredients that can increase your metabolic rate and thermogenesis. The latter means you also burn more calories after eating and during exercise.

In addition, PrimeShred’s blend of tyrosine and theanine promotes relaxation and focus, offering nootropic-like benefits.

Who Should Avoid PrimeShred?

Tyrosine in PrimeShred might affect the effectiveness of certain antidepressants like MAOI.

Price

• A one-time purchase of 1 month supply costs $59.99 or $47.99 for subscribers

Dosage

• 3 capsules 20 minutes before breakfast

User Review

PrimeShred seems to be delivering on its promise to its users, with one Amazon customer noticing a boost in energy and focus and a slight drop in appetite [5]. On the other hand, one Trustpilot reviewer was frustrated with delays, mentioning that their order hadn’t arrived after a week with no updates [6].

>>Learn more about PrimeShred on the official page

5. CalmLean – Best Stim-Free Formula

Pros

• Doesn’t contain stimulants
• 67-day refund policy
• Ingredients backed by published research

Cons

• Not as potent as other supplements

Who Is CalmLean Best For?

CalmLean is one of the best weight loss supplements for those who are sensitive to caffeine. It offers natural ingredients like cayenne to raise your body temperature and support fat-burning. There’s also ForsLean, which may reduce insulin and prevent fat storage.

Who Should Avoid CalmLean?

Active individuals who need a more stimulating supplement may look for more potent options.

Price

• 1 month supply costs $59.99
• 3 months supply costs $169.00
• 6 months supply costs $319.00

Dosage

• 2 capsules with water daily

User Review

CalmLean seems to be a hit-or-miss for users. One Amazon reviewer appreciated how it made them feel, especially after easing into it with a lower dose [7]. Meanwhile, another customer was unimpressed, claiming it had no effect and wasn’t worth the investment [8].

>>Get CalmLean on the official website

6. Trimtone – Best for Women

Pros

• Easy one-capsule-a-day dosage
• Save 20% when you subscribe
• 100-day money-back guarantee

Cons

• Key ingredients only available in minimal quantities

Who Is Trimtone Best For?

Trimtone is one of the best weight loss supplements for women who are always on the go and don’t have the time to meticulously plan every meal or spend hours at the gym. Expect the benefits of ingredients like glucomannan, which is popular for reducing appetite, and caffeine, which may boost metabolism.

Who Should Avoid Trimtone?

Trimtone is not recommended for pregnant or nursing women.

Price

• A one-time purchase of 1 month supply costs $39.99 or $31.99 when you subscribe

Dosage

• 1 capsule with water 30 minutes before breakfast

User Review

Trimtone seems to work well for some, offering metabolism support and an energy boost. One customer raved about its benefits and planned to repurchase [9]. Meanwhile, another user on Amazon noted that while it did help curb appetite, it also caused jitters and nervousness after taking the recommended dose [10].

>>Get Trimtone from the official website

7. Instant Knockout Cut – Best for Men

Pros

• Contains essential vitamins
• Freebies with bulk orders
• Vegan-friendly capsules

Cons

• High caffeine content

Who Is Instant Knockout Cut Best For?

Designed for men aiming to lower their body weight, Instant Knockout Cut provides essential vitamins such as D, B5, and B12, which are often insufficient in male diets, particularly those focused on weight gain through increased calorie intake.

Who Should Avoid Instant Knockout Cut?

Although one of the best weight loss supplements for men, Instant Knockout Cut is not advisable for people with gastrointestinal conditions. It contains cayenne pepper seeds, which may exacerbate their symptoms.

Price

• 1 month supply costs $65.00
• 2 months supply costs $130.00
• 4 months supply costs $195.00

Dosage

• 1 capsule with water 4 times daily

User Review

One customer on the official website credited Instant Knockout Cut with taking their fitness journey to the next level [11]. That said, not everyone had the same experience—another Amazon user reported seeing no results and promised they wouldn’t buy it again [12].

>>Explore more benefits of Instant Knockout Cut 

8. Zotrim – Best for Appetite Control

Pros

• Subscribers get 20% off with freebies 
• Backed by 5 clinical studies and 10 expert-approved papers
• 100-day money-back guarantee

Cons

• Free delivery only in the United States

Who Is Zotrim Best For?

Those who struggle with cravings will find Zotrim beneficial. It features yerba mate, damiana, and guarana, which may aid in appetite suppression. The caffeine in guarana encourages your body to burn fat. Moreover, B vitamins can provide extra energy.

Who Should Avoid Zotrim?

Those sensitive to caffeine might find Zotrim too stimulating. CalmLean is a caffeine-free alternative to try instead.

Price

• A one-time purchase of 1 month supply costs $59.99 or $47.99 when you subscribe

Dosage

• 2 tablets of Zotrim with water or a cold drink 3 times daily before meals

User Review

For balanced reviews of Zotrim, we suggest looking at discussions on platforms like Reddit or Quora.

>>Buy Zotrim here

9. Transparent Labs Body Recomp – Best for Improving Body Composition

Pros

• Subscribers save $6 and get free shipping
• Non-GMO and gluten-free
• 3rd-party lab tested

Cons

• No free delivery

Who Is Transparent Labs Body Recomp Best For?

Improving your body composition, which refers to the ratio of muscle to fat in your body, involves a combination of healthy eating, regular exercise, and consistent lifestyle habits. Maintaining a healthy body composition is crucial for reducing the risk of various health issues, including heart disease, type 2 diabetes, and certain types of cancer. If this is your goal, then Body Recomp should be your go-to weight loss supplement.

Who Should Avoid Transparent Labs Body Recomp?

If you have high blood pressure, avoid using products with Capsimax (like Body Recomp) as it may worsen your condition.

Price

• A one-time purchase of 1 month supply costs $54.99 or $49.49 when you subscribe

Dosage

• 2 capsules with water 30-60 minutes before a meal twice daily

User Review

Transparent Labs Body Recomp impressed verified buyers on the official page with its quick effects, with one person on the website noticing a difference within just a week. However, another user found the appetite suppression helpful but experienced some nausea as a side effect [13].

>>Learn more about Transparent Labs Body Recomp

How Do Weight Loss Supplements Actually Work?

Multi-ingredient weight loss supplements, like the ones we reviewed, work through various mechanisms. They often combine ingredients that target different aspects of weight management, like cayenne pepper and coffee beans.

For instance, some may increase metabolism and fat burning through stimulants like caffeine or green tea extract. In contrast, others aim to reduce appetite or cravings using ingredients like fiber or appetite suppressants.

Some weight loss supplements even focus on increasing protein intake, which can help build and maintain muscle mass while keeping you feeling full and satisfied. This can be easily achieved by incorporating whey protein into your daily diet through shakes, smoothies, or even baking.

However, the effectiveness of the best supplements for weight loss varies greatly depending on the specific ingredients, their dosages, and individual responses. We recommend speaking with a healthcare professional before using any supplement.

>>Get PhenQ on the official website

Common Ingredients in the Best Weight Loss Supplements

The best weight loss supplements often combine various ingredients that aim to promote weight loss through different mechanisms. Here are some popular options and the science behind their benefits:

• Caffeine: High caffeine intake is often linked to weight loss through increased thermogenesis (heat production) and fat oxidation, as well as suppressed levels of leptin, a hormone that regulates appetite [14].
• Green Tea Extract: A study found that 12 weeks of 856.8 mg green tea extract treatment led to significant weight loss, smaller waist circumference, and lower total cholesterol levels in women with central obesity, with no reported side effects [15].
• Cayenne Pepper or Capsimax: While capsaicin, the active compound in cayenne pepper, is often touted for weight loss, a meta-analysis indicates its impact on BMI, body weight, and waist circumference in overweight or obese individuals is likely modest [16]. 
• Glucomannan: Studies have shown that 2-4 grams of glucomannan daily is well-tolerated and leads to significant weight loss in overweight and obese individuals. This benefit likely comes from increased satiety and greater fecal energy loss [17].
• Chromium: A paper on chromium’s health benefits found that supplementation in the form of chromium picolinate resulted in a small but statistically significant reduction in both body weight and body fat percentage [18].

Buying Guide

Buying weight loss supplements requires careful consideration:

• First, prioritize supplements backed by scientific research, looking for studies on the specific ingredients and their dosages.
• Then, consult your doctor before starting any new supplement, especially if you have existing health conditions or take medications, as some ingredients can interact negatively.
• Focus on lifestyle changes like diet and exercise as the foundation for weight loss, viewing supplements as potentially supportive, not magical, solutions.
• Finally, be realistic about expectations, as even effective supplements typically produce modest results.

>>Get PhenQ on the official website

Best Weight Loss Supplements: FAQs

Here, we answer a few frequently asked questions about the best dietary supplements for weight loss.

What Is the Best OTC Weight Loss Supplement?

PhenQ is our #1 option among the best natural supplements for weight loss, but if you’re looking for FDA-approved pills, go for Alli (orlistat). It works by blocking the absorption of fatty acids, but its effectiveness is modest, and it can cause unpleasant side effects.

Did Kelly Clarkson Take Ozempic To Lose Weight?

Kelly Clarkson has publicly stated that she did not use Ozempic for weight loss. While she confirmed using a weight loss medication prescribed by her doctor, she clarified that it was a different medication that helps regulate blood sugar levels.

How To Lose 20 Pounds in a Month?

Losing 20 pounds in a month is generally considered unsafe and unsustainable for most people. Healthy weight loss typically occurs at a rate of 1-2 pounds per week. Rapid weight loss attempts often involve extreme calorie restriction or excessive exercise, which can lead to nutrient deficiencies, muscle loss, and other health problems.

How Did Adele Lose Weight?

Adele’s weight loss was achieved through a combination of dietary changes and regular exercise. She reportedly followed the Sirtfood Diet, which emphasizes foods high in sirtuin activators, and incorporated intermittent fasting into her routine. Additionally, she engaged in a consistent exercise regimen that included both strength training and cardio.

Best Weight Loss Supplements: Final Thoughts

Overall, we discovered that PhenQ stands out among the best over-the-counter weight loss supplements on the market. It contains scientifically backed ingredients that stimulate thermogenesis, increase energy, and suppress appetite to help you reach your weight loss goals and potentially improve your body mass index.

Remember that supplements can have varying effects on different individuals. Make sure to do your research and select the best weight loss supplements that best meet your specific needs and health status.

>>Get PhenQ on the official website

References

1. “Appetite Suppressant.” PhenQ (USA), https://phenq.com/pages/appetite-suppressant. Accessed 11 Feb. 2025.
2. “Tracie Tooker Gave PhenQ 2 Stars. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/66e4abff88d99d3a4b6ae730. Accessed 11 Feb. 2025.
3. “John Lane Gave Phen24 Fat Burner Diet 4 Stars. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/6798e9802dde18853b8a63e0. Accessed 11 Feb. 2025.
4. “Michael Sitton Gave Phen24 Fat Burner Diet 1 Star. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/67545de49aec7cef944f1c70. Accessed 11 Feb. 2025.
5. “Check out This Amazon Review of PrimeShred Thermogenic Appetite Suppressant Pills for Men, Triple Action Weight Loss Supplement with Caffeine, Energy Booster for Workouts (90 Capsules).” Amazon.Com, https://www.amazon.com/gp/aw/review/B0BX3Q3MTM/R1HKWA34WJLLCP?ie=UTF8&ASIN=B0BX3Q3MTM. Accessed 11 Feb. 2025.
6. “Ralph Gave Primeshred.Com 1 Star. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/6276b8da166eb7ecbf401bdb. Accessed 11 Feb. 2025.
7. “Check out This Amazon Review of PrimeGENIX CalmLean Stimulant-Free Fat Burner.” Amazon.Com, https://www.amazon.com/gp/aw/review/B0BT16JVZ2/R2JIFI2TVJBAVX?ie=UTF8&ASIN=B0BT16JVZ2. Accessed 11 Feb. 2025.
8. “Check out This Amazon Review of PrimeGENIX CalmLean Stimulant-Free Fat Burner.” Amazon.Com, https://www.amazon.com/gp/aw/review/B0BT16JVZ2/R12PXUTJHRM1PZ?ie=UTF8&ASIN=B0BT16JVZ2. Accessed 11 Feb. 2025.
9. “Trimtone – Female Fat Burner.” HealthNutrition, https://healthnutrition.com/products/trimtone. Accessed 11 Feb. 2025.
10. “Check out This Amazon Review of TRIMTONE Weight Loss Pills Women Mood Boosting Formula, Appetite Suppressant & Detox Cleanse Fat Burners for Women, Diet Pills That Work Fast for Women, Optimal for Belly Fat – 30 Capsules (1 Per Day).” Amazon.Com, https://www.amazon.com/gp/aw/review/B0C1JM1619/R7FMSBFTXKAXX?ie=UTF8&ASIN=B0C1JM1619. Accessed 11 Feb. 2025.
11. “Real Customer Testimonials.” Instant Knockout, https://www.instantknockout.com/en-us/testimonials. Accessed 11 Feb. 2025.
12. “Check out This Amazon Review of Roar Ambition Instant Knockout Fat Burner for Men & Women – All Natural Ingredients with Glucomannan, Green Tea Extract, Cayenne Pepper Seeds and More.” Amazon.Com, https://www.amazon.com/gp/aw/review/B0916798ND/R2AZRCSEL73Q36?ie=UTF8&ASIN=B0916798ND. Accessed 11 Feb. 2025.
13. “PhysiqueSeries Recomp Fat Burner for Men & Women.” Transparent Labs, https://www.transparentlabs.com/products/fat-burner. Accessed 11 Feb. 2025.
14. Westerterp-Plantenga, Margriet S., et al. “Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation.” Obesity Research, vol. 13, no. 7, 2005, pp. 1195–1204, doi:10.1038/oby.2005.142.
15. Chen, I. Ju, et al. “Therapeutic Effect of High-Dose Green Tea Extract on Weight Reduction: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Clinical Nutrition (Edinburgh, Scotland), vol. 35, no. 3, 2016, pp. 592–599, doi:10.1016/j.clnu.2015.05.003.
16. Zhang, Wensen, et al. “The Effects of Capsaicin Intake on Weight Loss among Overweight and Obese Subjects: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.” The British Journal of Nutrition, vol. 130, no. 9, 2023, pp. 1645–1656, doi:10.1017/S0007114523000697.
17. Keithley, Joyce, and Barbara Swanson. “Glucomannan and Obesity: A Critical Review.” Alternative Therapies in Health and Medicine, vol. 11, no. 6, 2005, pp. 30–34, https://pubmed.ncbi.nlm.nih.gov/16320857/.
18. “Chromium.” Nih.Gov, https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/. Accessed 11 Feb. 2025.