Selective Androgen Receptor Modulator Rad 140 Showing Promising Results in Protecting the Brain From Alzheimer’s Disease

Updated on November 23, 2022

When it came to defending hippocampus neurons from induced cellular death, RAD140 was just as efficient as testosterone. This is significant because learning and memory are two functions in which the Hippocampus, a complex brain structure, plays a key part.

Because the administration of a MAPK inhibitor prevented RAD140’s neuroprotection, this function relied on Mitogen-Activated Protein Kinase (MAPK) signaling. Additionally, the powerful neuroexcitatory substance kainic acid could not harm the rat brains when exposed to RAD140.

RAD 140 demonstrated tissue-specific androgenic activity without deleterious effect on the prostate in a rat model lacking androgen. The brain showed signs of androgenic consequences.

Castrated rats with low testosterone levels showed a reduction in the number of androgen receptors in the brain. This is significant because androgens have a role in how the central nervous system is structured and operates. RAD 140 showed actions that activated androgenic gene regulation in those androgen-deficient rat models.

The research results show the preliminary preclinical effectiveness of a SARM in activities neuroprotective relevant to Alzheimer’s disease and similar neurodegenerative illnesses.

RAD 140 is excellent for boosting muscle growth and lowering body fat. Some people think it enhances their exercise-related quickness, stamina, and endurance.

RAD 140 produces noticeable benefits in at least 3 to 4 weeks of use. Most people use PCT since RAD140 often suppresses testosterone.

RAD 140 is showing promise in preventing Alzheimer’s disease in the brain.

The protective effects of androgens on the brain are significant. They can boost brain cell development, enhance memory, and reduce amyloid-beta buildup. One of the primary causes of Alzheimer’s disease is amyloid-beta plaque.

RAD140 protected brain nerves against amyloid-beta plaque damage in rat research. Additionally, RAD 140 Testolone functioned well in neurotoxic defense.

Although some RAD 140 users claim to sleep better, no studies support this claim. The same is true of its alleged capacity to improve sexual performance, but this may be related to its testosterone-mimicking properties.

In cultured rat neurons and the male rat brain, SARM RAD140 was tested for its capacity to provide neuroprotection, a crucial neural action of endogenous androgens important for neural health and resistance to neurodegenerative diseases. RAD140 was equally effective as testosterone at preventing cell death brought on by apoptotic insults in cultured hippocampal neurons. As shown by increased ERK phosphorylation and inhibition of protection by the MEK inhibitor U0126, RAD 140 neuroprotection depended on MAPK signaling from a mechanical perspective. Importantly, the rat kainite lesion model demonstrated that RAD140 was also neuroprotective in vivo. The effects of RAD 140 on peripheral tissue-specific androgen action that largely spared the prostate, neural efficacy as shown by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death brought on by systemic administration of the excitotoxin kainite were all demonstrated in studies with gonadectomized, adult male rats. These novel findings demonstrate the preliminary preclinical efficacy of a SARM in neuroprotective actions relevant to Alzheimer’s disease and associated neurodegenerative diseases.

Rad 140 is a possible Alzheimer’s disease medication.

Since there is no treatment for Alzheimer’s, the illness will inevitably advance. Additionally, this implies that neuronal death is unavoidable. Because of this, proteins and plaques form a vicious cycle that kills brain cells, and scientists are working to discover a cure. Fortunately, RAD140 may provide the protection the brain requires since several studies strongly imply that it may help prevent cell death linked to Alzheimer’s and other neurodegenerative disorders.

The formation of amyloid beta plaques and tau protein tangles, which obstruct cellular communication and cause brain cell death, is a key idea for how Alzheimer’s disease progresses.

According to research, androgens may contribute to the development of Alzheimer’s disease. Therefore, early androgen receptor targeting may aid in treating or preventing the illness. According to studies, decreased testosterone was detected in the brain both during and before an Alzheimer’s clinical diagnosis. This implies that androgens may be used to treat conditions like Alzheimer’s. Many companies that offer SARMs for sale also sell RAD-140. 

The Editorial Team at Healthcare Business Today is made up of skilled healthcare writers and experts, led by our managing editor, Daniel Casciato, who has over 25 years of experience in healthcare writing. Since 1998, we have produced compelling and informative content for numerous publications, establishing ourselves as a trusted resource for health and wellness information. We offer readers access to fresh health, medicine, science, and technology developments and the latest in patient news, emphasizing how these developments affect our lives.