Longevity supplements are the vitamins and nutrients that are used to prolong the lifespan of a person. Experts believe that the proper diet and exercise can promote long and healthy life. Studies have shown diet of most Americans is deficient in key nutrients that result in shortened lifespan and increased risk of cardiovascular diseases. According to the Triage Theory, when our body is deficient in essential nutrients, the micronutrients are used for short-term survival while longevity genes are disabled.
Therefore experts recommend that appropriate dietary supplements can prevent premature aging and promote longevity. (Ames 2018)
Longevity vitamins are very popular in the United States, especially among the elderly. According to Johns Hopkins Medicine, about twelve Billion Dollars are spent each year on multivitamins. However, most people don’t know which nutrient is most suitable for them.
There are a variety of vitamins that are claimed to be the best longevity supplements. Some of the best longevity activator vitamins are Nicotinamide adenine dinucleotide (NAD+), Omega-3 fatty acid, Coenzyme Q10, Reveratrol (Zenith Labs Longevity Activator), Vitamin B Complex, Probiotics and Prebiotics. A lot of natural longevity herbs are also available, like Fish oil, mushroom extract (longevity botanicals lion’s mane) and longevity blood pressure formula. (Ames 2018)
Nicotinamide Adenine Dinucleotide or NAD+ is one of the best longevity supplements backed by many high-quality studies. It controls the metabolism of the body by acting as a cofactor of various enzymatic reactions. About 500 chemical reactions in humans and animals require NAD+ as a cofactor. Most of the functions of the NAD+ are mediated by two enzymes, namely Sirtuins and Poly ADP Ribose Polymerases (PARP). Both of these enzymes have various subtypes that perform different functions.
One of the most important functions of the NAD+ is boosting longevity. NAD supports longevity by preventing oxidative damage, increasing DNA repair, and acting as an anti-oxidant. It also stabilizes Telomerase and improves mitochondrial dysfunction. All of these factors delay the onset of aging and promote a healthy life. Various studies have also shown that most of the effects of aging are due to a decreased level of NAD+ in the body. So it is necessary to maintain an optimum level of NAD to avoid these problems.
Diabetes is another metabolic disease that results in impaired synthesis of NAD+ in the body resulting in premature aging. Research has shown that NAD+ supplementation increases muscles’ sensitivity to insulin, promoting signalling and remodelling of the body. All of these factors decrease the risks of diabetes and premature aging. (Yoshino et al. 2021)
Neurodegenerative diseases are the diseases of the brain that deteriorate over time, resulting from impaired metabolism and increased neuro-inflammation. Examples of these diseases include Alzheimer’s Disease, Parkinson Disease, Huntington disease and retinal degenerative diseases. Advancements in molecular technologies have demonstrated that age-related decline in NAD+ level resulting in mitochondrial dysfunction is the underlying mechanism in these disorders. (Hikosaka et al. 2021) Studies have shown that NAD supplementation attenuates DNA damage, decrease neuro-inflammation, and cellular aging that improve symptoms of Alzheimer’s Disease, Parkinson’s Disease and retinal degeneration. (Hou et al. 2021; Jadeja et al. 2020)
NAD+ acts as an anti-cancer and boosts immunity by regulating the cellular inflammatory response. There are two main components of the immune system: innate and adaptive, and NAD+ supplementation supports them both. NAD also plays a role in the proliferation, reprogramming and survival of the immune cells. It prevents the over activations of the inflammatory cytokines by inhibiting the action of PARP-1, resulting in reduced inflammation. Sirtuins are NAD-dependent enzymes that play a crucial role in supporting the immune system by regulating NF-kB. (Navas and Carnero 2021)
Effects of NAD+ supplementation on human health
[This picture has been taken from open access article available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515]
Now that we have established that maintaining an adequate level of NAD is essential for longevity, chronic diseases and overall health, let’s discuss how can we boost our NAD level?. NAD+ levels can be increased naturally by caloric restriction, regular exercise, good quality sleep and a balanced diet.(Poljsak, Kovač, and Milisav 2020) Food items that are rich in NAD+ level include Dairy products, whole grains, fish, beef, fruits and vegetables. Learn more ways to boost NAD+ level naturally by checking out this article 6 Foods naturally rich in NAD+ and What Boosts NAD+ level naturally.
It usually becomes very challenging to maintain an optimum level of NAD in the body when age-related declines occur. Moreover, it is generally not possible for us to eat a perfect diet, and most of us search for an easy solution. Researches have shown that pharmacological therapies are usually required to protect against age-related decline. (Peluso et al. 2022)
To tackle this problem, we have designed NAD+ products that are easy to use and very effective at boosting the NAD+ level in the body. These NAD+ supplements are available in various forms like transdermal patches, sublingual lozenges etc.
NAD+ transdermal patches are very popular because they are easy to use and provide a continuous and smooth dose of NAD for a longer time. Sublingual lozenges are placed under the tongue, and medicine is absorbed quickly. The sublingual route is considered more effective than the oral because the drug is absorbed quickly and more drug can reach the blood compared to oral tablets. (Singh et al. 2017)
Ames, Bruce N. 2018. “Prolonging Healthy Aging: Longevity Vitamins and Proteins.” Proceedings of the National Academy of Sciences 115 (43): 10836 LP – 10844. https://doi.org/10.1073/pnas.1809045115.
Hikosaka, Keisuke, Keisuke Yaku, Keisuke Okabe, and Takashi Nakagawa. 2021. “Implications of NAD Metabolism in Pathophysiology and Therapeutics for Neurodegenerative Diseases.” Nutritional Neuroscience 24 (5): 371–83. https://doi.org/10.1080/1028415X.2019.1637504.
Hou, Yujun, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, Mark P Mattson, Deborah L Croteau, and Vilhelm A Bohr. 2021. “NAD<Sup>+</Sup> Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer’s Disease via CGAS–STING.” Proceedings of the National Academy of Sciences 118 (37): e2011226118. https://doi.org/10.1073/pnas.2011226118.
Jadeja, Ravirajsinh N, Menaka C Thounaojam, Manuela Bartoli, and Pamela M Martin. 2020. “Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration.” Edited by Ryoji Nagai. Oxidative Medicine and Cellular Longevity 2020: 2692794. https://doi.org/10.1155/2020/2692794.
Navas, Lola E, and Amancio Carnero. 2021. “NAD+ Metabolism, Stemness, the Immune Response, and Cancer.” Signal Transduction and Targeted Therapy 6 (1): 2. https://doi.org/10.1038/s41392-020-00354-w.
Peluso, Augusto, Mads V Damgaard, Marcelo A S Mori, and Jonas T Treebak. 2022. “Age-Dependent Decline of NAD+— Universal Truth or Confounded Consensus?” Nutrients. https://doi.org/10.3390/nu14010101.
Poljsak, Borut, Vito Kovač, and Irina Milisav. 2020. “Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD(+) Amount at the Cellular Level?” Oxidative Medicine and Cellular Longevity 2020 (December): 8819627. https://doi.org/10.1155/2020/8819627.
Singh, Narinder, Anjali Joshi, Amrit Pal Toor, and Gaurav Verma. 2017. “Chapter 27 – Drug Delivery: Advancements and Challenges.” In Micro and Nano Technologies, edited by Ecaterina Andronescu and Alexandru Mihai B T – Nanostructures for Drug Delivery Grumezescu, 865–86. Elsevier. https://doi.org/https://doi.org/10.1016/B978-0-323-46143-6.00027-0.
Yoshino, Mihoko, Jun Yoshino, Brandon D Kayser, Gary J Patti, Michael P Franczyk, Kathryn F Mills, Miriam Sindelar, et al. 2021. “Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women.” Science (New York, N.Y.) 372 (6547): 1224–29. https://doi.org/10.1126/science.abe9985.
Longevity supplements are used to make the lifespan of an individual long and healthy. Various longevity vitamins are available in the market like NAD+, Omega-3 fatty acid, Coenzme Q10, Reveratrol (Zenith Labs Longevity Activator), creatine longevity, and Probiotics. NAD+ is considered the best longevity supplement as it is backed by many high-quality studies. NAD+ level can be boosted by fasting, exercise, a healthy diet, NAD transdermal patches and sublingual lozenges.
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